Could not open key Software\Microsoft\ASP.Net\4.0.30319.0. Verify that you have sufficient access to that key, or contact your support personnel

This problem can occur when installing a web project that has been built using VS2010.

There is a new property within VS2010 web setup projects called ‘ASPNETVersion’  which defaults to “4.0.30319.0″. This obviously causes an issue if the web project is being deployed on a server that only has ASP.Net 2 installed.

Luckily the fix is easy:

• Open the setup project
• Change the “ASPNETVersion” property from “4.0.30319.0″ to “2.0.50727.0″
• Rebuild the setup project
• Reinstall on the target server